Professor of Microbiology and Immunology
Director: Center for Synthetic Immunity
Program Director: Immunology Program

Contact information

Department of Microbiology and Immunology
The Geisel School of Medicine at Dartmouth
6W Borwell Research Building
One Medical Center Drive
Lebanon NH 03756 

E-mail: Center.for.Synthetic.Immunity@dartmouth.edu
Telephone: 603-650-8675

My laboratory is interested in designing cellular and protein immunotherapeutics for use in cancer and other diseases. We develop chimeric antigen receptors (CARs) and expression systems to regulate their function. We focus our work on NK cells and CD8 T cells, and we use innate immune receptors as a means to develop novel therapeutics for cancer. 

Selected Publications:

Spear P, Wu MR, Sentman ML, Sentman CL
NKG2D ligands as therapeutic targets.
Cancer Immun 2013; 13:8
PMID: 23833565 

Spear P, Barber A, Sentman CL
Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors.
Oncoimmunology 2013 Apr 1; 2(4):e23564
PMID: 23734311

Spear P, Barber A, Rynda-Apple A, Sentman CL
NKG2D CAR T-cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors.
Immunol Cell Biol 2013 Jul; 91(6):435-40
PMID: 23628805

Zhang T, Sentman CL
Mouse tumor vasculature expresses NKG2D ligands and can be targeted by chimeric NKG2D-modified T cells.
J Immunol 2013 Mar 1; 190(5):2455-63
PMID: 23355740

Meehan KR, Talebian L, Tosteson TD, Hill JM, Szczepiorkowski Z, Sentman CL, Ernstoff MS
Adoptive cellular therapy using cells enriched for NKG2D+CD3+CD8+T cells after autologous transplantation for myeloma.
Biol Blood Marrow Transplant 2013 Jan; 19(1):129-37
PMID: 22975165

Zhang T, Wu MR, Sentman CL
An NKp30-based chimeric antigen receptor promotes T cell effector functions and antitumor efficacy in vivo.
J Immunol 2012 Sep 1; 189(5):2290-9
PMID: 22851709 

Spear P, Barber A, Rynda-Apple A, Sentman CL
Chimeric antigen receptor T cells shape myeloid cell function within the tumor microenvironment through IFN-γ and GM-CSF.
J Immunol 2012 Jun 15; 188(12):6389-98
PMID: 22586039

Iyori M, Zhang T, Pantel H, Gagne BA, Sentman CL
TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells.
J Immunol 2011 Sep 15; 187(6):3087-95
PMID: 21832159

Talebian L, Wu JY, Fischer DA, Hill JM, Szczepiorkowski ZM, Ernstoff MS, Sentman CL, Meehan KR
Novel mobilization strategies to enhance autologous immune effector cells in multiple myeloma.
Front Biosci (Elite Ed) 2011 Jun 1; 3:1500-8
PMID: 21622154

Barber A, Sentman CL
NKG2D receptor regulates human effector T-cell cytokine production.
Blood 2011 Jun 16; 117(24):6571-81
PMID: 21518928