CAR T cells

All types of cancer can be targeted by chimeric antigen receptor (CAR) effector cells. CARs are receptors designed to recognize specific target molecules on tumor cells and activate immune cells. CARs direct killing of tumor cells and local cytokine production that results in tumor eradication and fundamentally alters the tumor microenvironment to induce host anti-tumor immunity and inhibit tumor cell growth.

NKG2D CAR

This CAR recognizes NKG2D ligands on tumor cells and immuno-suppressive cells within the tumor microenvironment.

NKp30 CAR

This CAR recognizes ligands of NKp30 that include B7H6 and Bag6.

B7H6-specific CAR

B7H6-specific CARs use a variety of intracellular signaling domains. 

These CARs have in vitro and in vivo preclinical data to support further development.