CAR Safety

Although CAR T cell therapy can be very effective, there have been clinical reports of significant toxicity. Defining molecular mechanisms associated with toxicity following CAR infusion may lead to novel treatments or formulations to improve the safety of CAR therapy.

We have discovered key mechanisms that may control the extent of cytokine storm in CAR T cell treated animals. We are exploring additional mechanisms using CARs that target different antigens to understand the nature of CAR T cell toxicity and test new ways to prevent these adverse events following CAR T cell infusion.