Randolph J. Noelle, Ph.D.

Randolph J. Noelle, Ph.D.

We study mediators that control the development of adaptive immunity. Our current focus is on the role of retinoic acid in controlling immunity, elements of the immune microenvironment that control allograft tolerance and tumor immunity, and new members of the PD-L family that govern how monocytes regulate T cell responses. 

Contact Information

Department of Microbiology and Immunology
The Geisel School of Medicine at Dartmouth
Rubin Research Building
One Medical Center Drive
Lebanon NH 03756 

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Selected Publications

Ceeraz S, Nowak EC, Noelle RJ
B7 family checkpoint regulators in immune regulation and disease.
Trends Immunol 2013 Aug 13;
PMID: 23954143

Allie SR, Zhang W, Tsai CY, Noelle RJ, Usherwood EJ
Critical role for all-trans retinoic acid for optimal effector and effector memory CD8 T cell differentiation.
J Immunol 2013 Mar 1; 190(5):2178-87
PMID: 23338237

Stan RV, Tse D, Deharvengt SJ, Smits NC, Xu Y, Luciano MR, McGarry CL, Buitendijk M, Nemani KV, Elgueta R, Kobayashi T, Shipman SL, Moodie KL, Daghlian CP, Ernst PA, Lee HK, Suriawinata AA, Schned AR, Longnecker DS, Fiering SN, Noelle RJ, Gimi B, Shworak NW, Carriere C
The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition.
Dev Cell 2012 Dec 11; 23(6):1203-18
PMID: 23237953

Nowak EC, de Vries VC, Wasiuk A, Ahonen C, Bennett KA, Le Mercier I, Ha DG, Noelle RJ
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
J Exp Med 2012 Oct 22; 209(11):2127-35
PMID: 23008335

Guo Y, Pino-Lagos K, Ahonen CA, Bennett KA, Wang J, Napoli JL, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Turk MJ, Noelle RJ
A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells.
Cancer Res 2012 Oct 15; 72(20):5230-9
PMID: 22902413

Wasiuk A, Dalton DK, Schpero WL, Stan RV, Conejo-Garcia JR, Noelle RJ
Mast cells impair the development of protective anti-tumor immunity.
Cancer Immunol Immunother 2012 Dec; 61(12):2273-82
PMID: 22684520

Dalton DK, Noelle RJ
The roles of mast cells in anticancer immunity.
Cancer Immunol Immunother 2012 Sep; 61(9):1511-20
PMID: 22527244

de Vries VC, Pino-Lagos K, Nowak EC, Bennett KA, Oliva C, Noelle RJ
Mast cells condition dendritic cells to mediate allograft tolerance.
Immunity 2011 Oct 28; 35(4):550-61
PMID: 22035846

Pino-Lagos K, Guo Y, Brown C, Alexander MP, Elgueta R, Bennett KA, De Vries V, Nowak E, Blomhoff R, Sockanathan S, Chandraratna RA, Dmitrovsky E, Noelle RJ
A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity.
J Exp Med 2011 Aug 29; 208(9):1767-75
PMID: 21859847

Wang L, Rubinstein R, Lines JL, Wasiuk A, Ahonen C, Guo Y, Lu LF, Gondek D, Wang Y, Fava RA, Fiser A, Almo S, Noelle RJ
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
J Exp Med 2011 Mar 14; 208(3):577-92
PMID: 21383057