Further Reading

Systems Biology:

  • Lim, Lee, and Tang. 2013. Design Principles of Regulatory Networks: Searching for the Molecular Algorithms of the Cell. Molecular Cell. 49: 202-212.

  • Auslander and Fussenegger. 2013. From gene switches to mammalian designer cells: present and future prospects.Trends in Biotechnology. 31:155-168.

  • Bacchus, Aubel, and Fussenegger. 2013. Biomedically relevant circuit-design strategies in mammalian synthetic biology. Molecular Systems Biology. 9:691

  • Fischbach, Bluestone, and Lim. 2013. Cell-Based Therapeutics: The Next Pillar of Medicine. Science Translational Medicine. 5:179ps7

Chimeric Antigen receptors:

  • Sadelain, M., R. Brentjens, et al. (2013). "The basic principles of chimeric antigen receptor design." Cancer Discov 3(4): 388-398.

  • Spear, P., M. R. Wu, et al. (2013). "NKG2D ligands as therapeutic targets." Cancer Immun 13: 8.

  • Sentman, C. L. (2013). "Challenges of creating effective chimeric antigen receptors for cancer therapy." Immunotherapy 5(8): 783-785.

  • Park, T. S., S. A. Rosenberg, et al. (2011). "Treating cancer with genetically engineered T cells." Trends Biotechnol 29(11): 550-557.

  • Porter, D. L., B. L. Levine, et al. (2011). "Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia." N Engl J Med 365(8): 725-733.

  • Brentjens, R. J., M. L. Davila, et al. (2013). "CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia." Sci Transl Med 5(177): 177ra138.

  • Di Stasi, A., S. K. Tey, et al. (2011). "Inducible apoptosis as a safety switch for adoptive cell therapy." N Engl J Med 365(18): 1673-1683.

  • Brenner, M. K. and H. E. Heslop (2010). "Adoptive T cell therapy of cancer." Curr Opin Immunol 22(2): 251-257.

  • June, C. H. (2007). "Principles of adoptive T cell cancer therapy." Journal of Clinical Investigation 117(5): 1204-1212.